Bisocard Plus 5 / 12.5 mg 30 Tablets

Indications: Management of hypertension. * Contraindications: – Not to be used in patients with a known allergic hypersensitivity to any component of the product or to sulphonamide- derived drugs. – As with other beta-blocker && diuretic combinations, Bisocard Plus is contraindicated in cardiogenic shock, in cases of untreated cardiac failure, sinoatrial block, second or third degree atrioventricular block, marked bradycardia or extreme hypotension or severe asthma, severe peripheral arterial disease. – In patients with severe hypokalaemia or hyponatraemia. * Precautions: – In patients with prolonged PR conduction interval, poor cardiac reserve && peripheral circulatory disturbances. – In patients with ischaemic heart disease, treatment should not be withdrawn abruptly. – Bisoprolol, as cardioselective beta-blocker, is less likely to induce bronchospasm in patients with asthma, caution to be taken with patients suffering from asthma or history of obstructive airways disease. As well, it does not appear to have a hypoglycaemic effect but caution with diabetic patients since symptoms of hypoglycaemia may be masked. – Pregnancy, breast-feeding, myasthenia gravis; patients with a history of hypersensitivity reactions. – Low dose of hydrochlorothiazide reduces the elevation in uric acid levels normally associated with higher doses of hydrochlorothiazide. However, care should be taken in patients with a predisposition to gout or hyperuricaemia. – All patients treated with diuretics should receive periodic monitoring for signs of fluid or electrolyte imbalance. Hypokalaemia can be induced as a result of thiazide therapy && potassium levels should be checked. * Dosage && administration: Bisoprolol is an effective treatment of hypertension in once-daily doses of 2.5 to 40 mg, while hydrochlorothiazide is effective in doses of 12.5 to 50 mg. In clinical trials of bisoprolol/hydrochlorothiazide combination therapy using bisoprolol doses of 2.5 to 20 mg && hydrochlorothiazide doses of 6.25 to 25 mg, the antihypertensive effects increased with increasing doses of either component. One tablet of Bisocard Plus 5 to be taken daily in the morning. * Store at temperature not exceeding 30 degrees C, in dry place. * Manufactured by: GLOBAL NAPI PHARMACEUTICALS (GNP) – Egypt.